Cardiovascular System – Myocardial perfusion imaging

Cardiovascular System

Myocardial perfusion imaging

Imaging principle: To determine the state of coronary blood flow and the state of cardiomyocyte survival.
Normal cardiomyocytes selectively take up certain monovalent cationic compounds, which can be visualized by radionuclide labeling
Tracer uptake correlates positively with regional myocardial blood flow and correlates with cardiomyocyte function status
Normal myocardium develops, while ischemic or necrotic myocardium does not develop (defect) or image fades (sparse)
Nuclear Stress Myocardial Perfusion Imaging
Nuclear stress myocardial perfusion imaging (MPI) is a nuclear cardiology test that shows how well blood flows to the muscle of the heart (myocardium). This test is used to diagnose the presence or absence of coronary artery disease.

Here is a simple intro about MPI test.


A radioactive tracer (called Myoview) is injected into the patient’s bloodstream and is taken up by the heart tissue. A single photon emission computed tomography (SPECT) camera detects the radiation released by the tracer to produce images of the heart. Two sets of images are taken, one after an injection at rest and another after an injection during a stress test – either exercise stress on a treadmill or drug-induced stress with persantine (dipyridamole) medication, which simulates exercise.

MPI tests can help your doctor:

• Find out if there are narrowings or blockages in your coronary (heart) arteries if you have chest discomfort.
• If you have heart damage from a heart attack if your heart is not working normally.
• Determine if you should undergo a coronary angiogram.
• Decide whether you would benefit from coronary stent or bypass surgery to treat your chest discomfort or help an abnormal pumping function go back to normal.
• If a heart procedure you had to improve blood flow (stent, bypass) is working.
• How well your heart can handle physical activity.

Explain 201TI myocardial perfusion imaging to distinguish myocardial infarction and myocardial ischemia.

201TI enters cardiomyocytes and is related to the activity of sodium pump. The uptake of 201TI by the myocardium is a marker of myocardial cell activity and cell membrane integrity. Therefore, 201TI is a common method for identifying viable myocardium and necrotic myocardium.
201TI MPI is a characteristic manifestation of the diagnosis of reversible myocardial ischemia from early perfusion defects to delayed imaging perfusion defects.
The perfusion defects in the early and delayed necrotic myocardium were fixed without change.

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